Features of the metabolism of nitric oxide in normal state and inflammation

Autor:	A. N. Osipov, V. Yu. Titov, M. V. Kreinina, Anatoly F. Vanin
Rok vydání:	2013
Předmět:	Nitroso Compounds Chemistry Biophysics Inflammation Metabolism Normal state Nitric oxide chemistry.chemical_compound Biochemistry medicine medicine.symptom Nitrite No production Selectivity
Zdroj:	Biophysics. 58:676-688
ISSN:	1555-6654 0006-3509
Popis:	Brief analysis of the metabolism of nitric oxide in living cells in normal state and pathology and also the analysis of the causes, that hampered the progress of these studies, were carried out. It was established that most of physiological fluids, including blood, normally contain nitrite and non-thiolate nitroso compounds in concentration less than 100 nM. Literature data from different researchers on the normal range of nitrite concentration in plasma of healthy people from several hundreds of nM to several microM is probably the result of low selectivity of the methods used. But nitrite and non-thiolate nitroso compounds concentration in blood is dramatically increased in case of inflammatory diseases. It is proposed that the main mechanism for the production of these substances in blood is the nitrosyl iron complexes transformation by active oxygen species but not the activation of NO production as it was-considered previously.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c2374d1e3b68f4afed5bfbf42b2baa15 https://doi.org/10.1134/s0006350913050163 Zobrazit plný text záznamu Full text from SpringerLink