THE STEREO‐SPECIFICITY AND TEMPERATURE‐DEPENDENCE OF THE PERMEABILITY OF HUMAN ERYTHROCYTES TO ALDOSES

Autor: R. B. Fisher, I. A. Nimmo
Rok vydání: 1973
Předmět:
Zdroj: Quarterly Journal of Experimental Physiology and Cognate Medical Sciences. 58:153-161
ISSN: 0033-5541
DOI: 10.1113/expphysiol.1973.sp002200
Popis: Time-courses have been determined between 2·0°C and 25·5°C for the uptake of D(+) glucose, D(+) xylose and L(+) arabinose by human erythrocytes. They can be explained by assuming uptake is governed by a mobile carrier of the Widdas type. Since at any temperature the three aldoses have the same maximum rate of permeation but different half-saturation concentrations for the carrier, it is argued that they have a common carrier, and that the rate-limiting step in permeation is the translocation across the membrane of the carrier or carrier-aldose complex. Data are also given which suggest that α- and β-glucose have different half-saturation concentrations for the carrier.
Databáze: OpenAIRE