Synthesis of an iodine-labelled analogue of practolol: (S)-3-[4-(4-iodobut-3-encarboxamido)phenoxy]-1-isopropylaminopropan-2-ol (AMI-9S)
| Autor: | Younes Ben Tiba, Jean Paul Mathieu, Marcel Apparu, Pierre-Marc Léo, Laurent Mauclaire |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
chemistry.chemical_classification
Chloramine Organic Chemistry Iodide chemistry.chemical_element Nuclear magnetic resonance spectroscopy Iodine Biochemistry Medicinal chemistry Stannane Analytical Chemistry chemistry.chemical_compound chemistry Drug Discovery medicine Organic chemistry Radiology Nuclear Medicine and imaging Specific activity Enantiomer Practolol Spectroscopy medicine.drug |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 42:1195-1202 |
| ISSN: | 1099-1344 0362-4803 |
| DOI: | 10.1002/(sici)1099-1344(199912)42:12<1195::aid-jlcr275>3.0.co;2-r |
| Popis: | AMI-9S was synthesized in the S configuration with an enantiomeric purity of over 97% and labelled with iodine-123 with a specific activity of 300 Ci/mmol. Enantiomeric purity was determined by 19 F NMR spectroscopy following derivatisation using (R)-2-fluorophenylacetylchloride. Radioiodination was carried out from a vinylic stannane in the presence of iodide and chloramine T. |
| Databáze: | OpenAIRE |
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