3-Selenocyanate-indoles as new agents for the treatment of superficial and mucocutaneous infections
| Autor: | Luís Flávio Souza de Oliveira, Priscilla Maciel Quatrin, Rômulo Faria Santos Canto, Edilma Elaine Silva, Alexandre Meneghello Fuentefria, William Lopes, Mário Lettieri Teixeira, Gustavo Pozza Silveira, Luana Candice Genz Bazana, Daiane Flores Dalla Lana |
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| Rok vydání: | 2019 |
| Předmět: |
biology
Chemistry Mucocutaneous zone 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology biology.organism_classification 01 natural sciences Catalysis In vitro 0104 chemical sciences Microbiology Fungicide Comet assay Mechanism of action Materials Chemistry medicine Trichophyton medicine.symptom 0210 nano-technology Microsporum Ex vivo |
| Zdroj: | New Journal of Chemistry. 43:926-933 |
| ISSN: | 1369-9261 1144-0546 |
| Popis: | The development of resistance to the current antifungal agents is an alarming problem. Therefore, the search for new molecules capable of combating fungi infections is imperative. This study presents the in vitro activities of a library of seven 3-selenocyanate-indoles against Candida spp. and dermatophytes of the genera Trichophyton and Microsporum. The antifungal susceptibility of compounds 4a and 4b presented geometric mean values of 4.1 and 6.0 μg mL−1 against Candida spp. and 1.2 and 2.2 μg mL−1 against dermatophytes following the CLSI guidelines. The 3-selenocyanate-indole 4a showed a fungicidal effect against the whole fungal panel. The toxicological results revealed that the selenocyanates 4a and 4b did not show mutagenicity or cause changes in the human leukocyte cells and were classified as non-irritant by the ex vivo HET-CAM test. The mechanism of action of the 3-selenocyanate-indoles has not been clearly elucidated. However, a genotoxic potential in higher concentrations, observed by the comet assay, leads us to believe that these molecules have their mechanism of action related to the nucleus of the fungal cells. |
| Databáze: | OpenAIRE |
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