Stress oxydant et effets bénéfiques rénaux de la restriction sodée dans l’insulinorésistance chez le rat
| Autor: | Anne Dominique Lajoix, C. Rugale, Bernard Jover, C. Oudot |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Kidney business.industry Sodium chemistry.chemical_element Fructose medicine.disease_cause medicine.disease chemistry.chemical_compound Endocrinology Insulin resistance medicine.anatomical_structure chemistry Fibrosis Internal medicine Albuminuria Renal fibrosis Medicine medicine.symptom Cardiology and Cardiovascular Medicine business Oxidative stress |
| Zdroj: | Annales de Cardiologie et d'Angéiologie. 61:162-166 |
| ISSN: | 0003-3928 |
| Popis: | The aim of this work was to evaluate the influence of dietary sodium restriction on metabolic and renal changes associated with insulin resistance. At 8 weeks of age, rats received either a diet containing 60% fructose with or without sodium or a standard diet for 12 weeks. The insulin resistance and albuminuria induced by the high fructose diet were associated with a fibrosis and increase in oxidative stress in the kidney. The low salt diet prevented insulin resistance, renal fibrosis and albuminuria induced by the fructose diet. These beneficial effects on the kidney were associated with a decrease in kidney NADPH oxidase activity. Oxidative status is probably one of the major targets of the favourable effect of salt restriction on renal changes associated with insulin resistance, without excluding the involvement of other mechanisms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect