Effect of nitroglycerin on the free radical formation of myocardial mitochondria impaired by ethanol. Studies by electron spin resonance (ESR) spectrometry

Autor:	Tadashi Kamikawa, Mitate Yamamoto, Noboru Yamazaki, Yoshikazu Suzuki
Rok vydání:	1981
Předmět:	medicine.medical_specialty Ethanol Mitochondrion Intensity (physics) chemistry.chemical_compound Endocrinology Biochemistry chemistry Internal medicine Respiration medicine Myocardial Mitochondria Dog heart Cardiology and Cardiovascular Medicine Free Radical Formation Nitroglycerin medicine.drug
Zdroj:	Japanese Heart Journal. 22:627-635
ISSN:	1348-673X 0021-4868
DOI:	10.1536/ihj.22.627
Popis:	In order to investigate the direct metabolic effect of nitroglycerin on myocardium, its effect on mitochondrial free radical formation was studied in vitro, using the dog heart mitochondria impaired by ethanol. Free radical concentrations in state 4 respiration or the ratio of free radical concentrations in state 4 to state 1 was used as an index of mitochondrial function. Free radical concentrations were represented as ESR intensity.In normal control, ESR intensity increased from 0.115±0.030 (mean±SD) per mg protein in state 1 to 0.178±0.017 in state 4 (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c20429bbf1637e0c1d8eb69c21de07d9 https://doi.org/10.1536/ihj.22.627 Zobrazit plný text záznamu