Neuroprotective Effects of Kolaviron, a Biflavonoid Complex of Garcinia kola, on Rats Hippocampus against Methamphetamine-Induced Neurotoxicity
| Autor: | Margaret Olutayo Alese, Omamuyovwi M. Ijomone, Polycarp U. Nwoha, Augustine U. Obi, Olayemi K. Olaibi |
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| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
biology business.industry Garcinia kola Neurotoxicity Biflavonoid General Medicine Water maze Pharmacology Hippocampal formation Methamphetamine biology.organism_classification medicine.disease Neuroprotection chemistry Anesthesia medicine Hippocampus (mythology) business medicine.drug |
| Zdroj: | Macedonian Journal of Medical Sciences. 5:10-16 |
| ISSN: | 1857-5773 1857-5749 |
| Popis: | Aim: To investigate the protective effects of kolaviron on brain weight and behavioural performance and the histology of the hippocampus of adult Wistar rats following methamphetamine challenge. Materials and Methods: Twenty four adult Wistar rats weighing between 150-200 g, randomly assigned into four groups of six each (Groups A, B, C, D) were used for this research. Group A served as control, while groups B and C were given single dose methamphetamine (10 mg/kg) intraperitoneally after group C was pre-treated with kolaviron (200 mg/kg) for 7 days and group D received cornoil (vehicle for kolaviron) only. Results: High level of methamphetamine-induced stereotypic movement was observed, and the onset was delayed by kolaviron administration. Animals administered methamphetamine only, showed significantly poor behavioural performance on the water maze after treatment when compared to the other groups (P |
| Databáze: | OpenAIRE |
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