Evaluation of a Multiethnic Polygenic Risk Score Model for Prostate Cancer
| Autor: | Sarah S. Kalia, Adam S. Kibel, David V. Conti, Kathryn L. Penney, Anna Plym, Lorelei A. Mucci, Peter Kraft, Christopher A. Haiman |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
0303 health sciences Cancer Research education.field_of_study medicine.medical_specialty business.industry Population Odds ratio Disease medicine.disease Confidence interval Decile 03 medical and health sciences Prostate cancer 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine medicine Polygenic risk score Cumulative incidence education business 030304 developmental biology |
| Zdroj: | JNCI: Journal of the National Cancer Institute. 114:771-774 |
| ISSN: | 1460-2105 0027-8874 |
| Popis: | Polygenic risk scores (PRSs) of common genetic variants have shown promise in prostate cancer risk stratification, but their validity across populations has yet to be confirmed. We evaluated a multiethnic PRS model based on 269 germline genetic risk variants (261 were available for analysis) using an independent population of 13 628 US men. The PRS was strongly associated with prostate cancer but not with any other disease. Comparing men in the top PRS decile with those at average risk (40%-60%), the odds ratio of prostate cancer was 3.89 (95% confidence interval = 3.24 to 4.68) for men of European ancestry and 3.81 (95% confidence interval = 1.48 to 10.19) for men of African ancestry. By age 85 years, the cumulative incidence of prostate cancer for European American men was 7.1% in the bottom decile and 54.1% in the top decile. This suggests that the PRS can be used to identify a substantial proportion of men at high risk for prostate cancer. |
| Databáze: | OpenAIRE |
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