In Vitro Interaction Between Oral Hypoglycemic Drug And Herbal Sex Stimulants: Drug Interactions
| Autor: | Md. Nazmul Hossain, Nishat Akther, Robiul H. Bhuiyan, Muhammad Mosaraf Hossain, Md. Alauddin Alauddin, Md. Abdur Rahaman |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Libido
Drug business.industry media_common.quotation_subject 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Drug interaction Pharmacology medicine.disease complex mixtures 03 medical and health sciences 0302 clinical medicine Sexual dysfunction Erectile dysfunction Concomitant Diabetes mellitus Medicine Gliclazide medicine.symptom business medicine.drug media_common |
| Zdroj: | European Scientific Journal, ESJ. 12:238 |
| ISSN: | 1857-7431 1857-7881 |
| DOI: | 10.19044/esj.2016.v12n9p238 |
| Popis: | Sexual dysfunction is a common, underappreciated complication of diabetes. Male sexual dysfunction among diabetic patients can include disorders of libido, ejaculatory problems, and erectile dysfunction (ED). All three forms of male dysfunction can cause significant bother for diabetic patients and can affect their quality of life. Diabetic patients take oral hypoglycemic drug to control their diabetic as well as take herbal sex stimulants to control to increase the libido. The combined use of herbs and drugs has increased the possibility of herb-drug interactions. The study was undertaken to explore the herb-drug interactions. To investigate the herbdrug interactions an in vitro dissolution study in different simulated pH medium were performed. In this study gliclazide containing tablet of 80mg as oral hypoglycemic drug and different herbal sex stimulants available in local market were used. The release mechanism was explored and explained with zero order, first order and Higuchi equations to identify drug interaction. Higher percentage release of gliclazide was found at simulated phosphate buffer of pH 7.4 compared to gastric medium of pH 1.2 and also in presence of herbal sex stimulants. Increased release pattern of gliclazide by concomitant administration of herbal sex stimulants gives slightly higher absorption, which gives the indication of herb-drug interactions. |
| Databáze: | OpenAIRE |
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