Chronic alcohol alters rewarded behaviors and striatal plasticity

Autor:	Andrew Holmes, Bianca Noronha, Lauren DePoy, Marguerite Camp, Nicole A. Crowley, Tara Wright, Rachel A. Daut, David M. Lovinger
Rok vydání:	2014
Předmět:	Pharmacology Dorsum technology industry and agriculture Medicine (miscellaneous) Plasticity Chronic alcohol Psychiatry and Mental health Electrophysiology Neuroplasticity Dorsolateral striatum Prefrontal cortex Psychology Long-Term Synaptic Depression Neuroscience
Zdroj:	Addiction Biology. 20:345-348
ISSN:	1355-6215
DOI:	10.1111/adb.12131
Popis:	Chronic intermittent ethanol (CIE) alters neural functions and behaviors mediated by the dorsolateral striatum (DLS) and prefrontal cortex. Here, we examined the effects of prolonged (16-bout) CIE on DLS plasticity and DLS-mediated behaviors. Ex vivo electrophysiological recordings revealed loss in efficacy of DLS synaptically induced activation and absent long-term depression after CIE. CIE increased two-bottle choice drinking and impaired Pavlovian-to-instrumental transfer but not discriminated approach. These data suggest prolonged CIE impaired DLS plasticity, to produce associated changes in drinking and cue-controlled reward-seeking. Given recent evidence that less-prolonged CIE can promote certain dorsal striatal-mediated behaviors, CIE may drive chronicity-dependent adaptations in corticostriatal systems regulating behavior.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c1ec00004ee769bc482f894e502e68d2 https://doi.org/10.1111/adb.12131 Zobrazit plný text záznamu Plný text