| Autor: |
Adam Butler, Aitor Rodriguez-Casanova, Y. Li, Kerstin Haase, P. Van Loo, Kazuaki Chayama, Hiroshi Aikata, Atushi Ono, Masaki Ueno, S. Rodriguez Perales, A. Pequeno, Angel Diaz-Lagares, R. Abal, Mónica Martínez-Fernández, Javier Temes, Eva G. Alvarez, Daniel García-Souto, Bernardo Rodriguez-Martin, Clemency Jolly, Xavier Forns, Carmen Rivas, Hidewaki Nakagawa, P. Otero, Peter J. Campbell, Alicia L. Bruzos, Hiroki Yamaue, Martin Santamarina, Keiran Raine, Marta Tojo, Urtzi Garaigorta, Sonia Zumalave, Jose M. C. Tubio, Jorge Rodríguez-Castro, Sofía Pérez-del-Pulgar, Miguel Blanco, Jonas Demeulemeester, A. Oitaben, Jorge Zamora, Shinya Hayami, Raúl Torres-Ruiz, Adrian Baez-Ortega |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Most cancers are characterized by the somatic acquisition of genomic rearrangements during tumour evolution that eventually drive the oncogenesis. There are different mutational mechanisms causing structural variation, some of which are specific to particular cancer types. Here, using multiplatform sequencing technologies, we identify and characterize a remarkable mutational mechanism in human hepatocellular carcinoma caused by Hepatitis B virus, by which DNA molecules from the virus are inserted into the tumour genome causing dramatic changes in its configuration, including non-homologous chromosomal fusions and megabase-size telomeric deletions. This aberrant mutational process, present in at least 8% of all HCC tumours, is active early during liver cancer evolution and can provide the driver rearrangements that a cancer clone requires to survive and grow. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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