Michael addition of organocopper species to 3-[(E)-4,4,4-trifluorobut-2-enoyl]oxazolidin-2-ones

Autor:	Tomoya Kitazume, Takashi Yamazaki, Shoichi Sato, Noriyasu Shinohara
Rok vydání:	1999
Předmět:	Stereochemistry Organic Chemistry chemistry.chemical_element Optically active Biochemistry Copper Combinatorial chemistry Inorganic Chemistry chemistry Reagent Michael reaction Environmental Chemistry Moiety Molecule Lithium Physical and Theoretical Chemistry Selectivity
Zdroj:	Journal of Fluorine Chemistry. 97:91-96
ISSN:	0022-1139
DOI:	10.1016/s0022-1139(99)00034-2
Popis:	Investigation of Michael addition has been carried out using versatile organomagnesium or -lithium reagents in the presence of copper(I) species towards chiral 3-[(E)-4,4,4-trifluorobut-2-enoyl]oxazolidin-2-ones, and it was demonstrated that this route enabled us to successfully construct optically active molecules with a CF3 moiety at the chiral center in good yields as well as the high level of diastereofacial selectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c1d96e29140467179ea65c3df86e808a https://doi.org/10.1016/s0022-1139(99)00034-2 Zobrazit plný text záznamu Full Text from ScienceDirect