Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial

Autor: Armando Gomez-Ojeda, Gloria Patricia Sosa-Bustamante, Karla Paola Gutiérrez-Castro, Anaisa Genoveva Flores-Ramírez, Ma. Eugenia Garay-Sevilla, Juan Carlos Barrera-de León, Claudia Luevano-Contreras, Russell Caccavello, Alma Patricia Gonzalez, Alejandro Gugliucci
Rok vydání: 2021
Předmět:
Zdroj: European Journal of Pediatrics. 180:2493-2503
ISSN: 1432-1076
0340-6199
DOI: 10.1007/s00431-021-04064-5
Popis: Obesity can lead children and adolescents to an increased cardiovascular disease (CVD) risk. A diet supplemented with Plantago psyllium has been shown to be effective in reducing LDL-C and IL-6 in adolescents. However, there are no studies that have explored small-dense LDL (sdLDL) or HDL subclasses. The aim of this study was to evaluate the impact of a fiber dietary intervention on LDL and HDL subclasses in adolescents with obesity. In this parallel, double blind, randomized clinical trial, the participants were assigned to Plantago psyllium or placebo (10g/day for 7 weeks). We randomized 113 participants, and evaluated and analyzed 100 adolescents (50 in each group), 15 to 19 years with a body mass index of 29-34. We measured biochemical markers LDL and HDL subclasses using the Lipoprint system (Quantimetrix) and IL-6 by ELISA. Post-treatment there was a decrease in sdLDL between the groups 2.0 (0-5.0) vs 1 (0-3.0) mg/dl (p = 0.004), IL-6 median 3.32 (1.24-5.96) vs 1.76 (0.54-3.28) pg/ml, p
Databáze: OpenAIRE
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