Volatile organic compounds kill the white-nose syndrome fungus, Pseudogymnoascus destructans, in hibernaculum sediment
| Autor: | Emma W. Micalizzi, Myron L. Smith |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
030306 microbiology Immunology Zoology Sediment General Medicine Fungal pathogen Fungus Biology White-nose syndrome biology.organism_classification Applied Microbiology and Biotechnology Microbiology Hibernaculum 03 medical and health sciences Pseudogymnoascus destructans Genetics Molecular Biology 030304 developmental biology |
| Zdroj: | Canadian Journal of Microbiology. 66:593-599 |
| ISSN: | 1480-3275 0008-4166 |
| DOI: | 10.1139/cjm-2020-0071 |
| Popis: | Pseudogymnoascus destructans, the fungal pathogen that causes white-nose syndrome, has killed millions of bats across eastern North America and continues to threaten new bat populations. The spread and persistence of P. destructans has likely been worsened by the ability of this fungus to grow as a saprotroph in the hibernaculum environment. Reducing the environmental growth of P. destructans may improve bat survival. Volatile organic compounds (VOCs) are attractive candidates to target environmental P. destructans, as they can permeate through textured environments that may be difficult to thoroughly contact with other control mechanisms. We tested in hibernaculum sediment the performance of VOCs that were previously shown to inhibit P. destructans growth in agar cultures and examined the inhibition kinetics and specificity of these compounds. Three VOCs, 2-methyl-1-butanol, 2-methyl-1-propanol, and 1-pentanol, were fungicidal towards P. destructans in hibernaculum sediment, fast-acting, and had greater effects against P. destructans than other Pseudogymnoascus species. Our results suggest that use of these VOCs may be considered further as an effective management strategy to reduce the environmental exposure of bats to P. destructans in hibernacula. |
| Databáze: | OpenAIRE |
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