Modelling of blood component flexibility using quartz crystal microbalance

Autor:	Ramji S. Lakshmanan, Vitaly Efremov, Sinead M. Cullen, Barry J. Byrne, Anthony J. Killard
Rok vydání:	2014
Předmět:	Flexibility (anatomy) Chemistry Mechanical Engineering Analytical chemistry Quartz crystal microbalance Adhesion Dissipation Viscoelasticity medicine.anatomical_structure Adsorption Mechanics of Materials Chemical physics medicine General Materials Science Cell adhesion Layer (electronics)
Zdroj:	Journal of Biorheology. 28:45-54
ISSN:	1867-0474 1867-0466
Popis:	Quartz crystal microbalance (QCM) is a sensitive technique for real-time monitoring of cell adsorption, aggregation and cell-to-surface interaction processes. However, cell adhesion time courses are usually considered as merely qualitative, being presented in terms of QCM resonant frequency shift and/or changes in the dissipation parameter, the precise physical meanings of which are not derived. In the present study, a model of cell adhesion to the QCM sensor surface was proposed. The main output parameter of the model is the rigid mass density, Mr, being related to QCM resonant frequency and dissipation with a simple expression. From this, it can be determined that Mr is the mass density of the layer formed by all directly adhered parts of the cell, being rigidly coupled to the sensor surface. We postulate that the Mr(t) value is proportional to the number of cells adhered by the time t, and that the coefficient of this proportionality is strongly dependent on cell-to-surface interaction forces.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c1aea987e522825d5ed9cf7450d7bfc9 https://doi.org/10.17106/jbr.28.45 Zobrazit plný text záznamu