Asymmetric Synthesis of (R)-3-Hydroxy-2-methylpropanoate (‘Roche Ester’) and Derivatives via Biocatalytic CC-Bond Reduction

Autor:	Kurt Faber, Melanie Bonnekessel, Clemens Stueckler, Christoph K. Winkler
Rok vydání:	2010
Předmět:	Reaction rate chemistry.chemical_compound Biocatalysis Chemistry Stereochemistry organic chemicals Old yellow enzyme Enantioselective synthesis Stereoselectivity General Chemistry Roche ester
Zdroj:	Advanced Synthesis & Catalysis. 352:2663-2666
ISSN:	1615-4150
DOI:	10.1002/adsc.201000522
Popis:	Enoate reductases from the 'old yellow enzyme' family were employed for the asymmetric bioreduction of methyl 2-hydroxymethylacrylate and its O-allyl, O-benzyl and O-TBDMS derivatives to furnish (R)-configurated methyl 3-hydroxy-2-methylpropionate products in up to > 99% ee Variation of the O-protective group had little influence on the stereoselectivity, but a major impact on the reaction rate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c1a9959148a226723e73c5601ac04ebb https://doi.org/10.1002/adsc.201000522 Zobrazit plný text záznamu Plný text