| Autor: |
L. A. Sordahl, H. L. Stone, R. T. Dowell |
| Rok vydání: |
1981 |
| Předmět: |
|
| DOI: |
10.21236/ada105167 |
| Popis: |
The level of the sympathetic nervous system activity markedly increases during +Gz acceleration stress and this increase was implicated in the etiology of cardiac subendocardial hemorrhage associated with high sustained +Gz acceleration. The biochemical and physiological effect of high sustained +Gz acceleration was investigated in miniature swine. The animals were chronically instrumented to measure coronary flow and left ventricular pressure. In some animals blood samples were taken from the left atrium and coronary sinus. The results of these studies show that biochemical alteration occur in the myocardium and were present for up to 14 days following exposure to +Gz acceleration stress. Coronary blood flow decreased at higher +Gz levels while other signs of compromised coronary blood flow also were present following acceleration. Removal of portion of the sympathetic nerve system did not dramatically alter this response. These studies suggest that high sustained +Gz acceleration does cause myocardial damage in miniature swine and that this injury is not reduced a great deal by alteration of the sympathetic nervous system to the heart. It is not clear what role circulating catecholamines might play in this response. (Author) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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