Bioinformatic Tools for Genotyping of Klebsiella pneumoniae Isolates

Autor:	Matej Bezdicek, Martina Lengerová, Marketa Nykrynova, Denisa Maderankova, Helena Skutkova
Rok vydání:	2018
Předmět:	0301 basic medicine Phylogenetic tree biology Klebsiella pneumoniae 030106 microbiology Computational biology biology.organism_classification 03 medical and health sciences Molecular typing 030104 developmental biology Identification (biology) Typing Cluster analysis Genotyping
Zdroj:	Advances in Intelligent Systems and Computing ISBN: 9783319912103 ITIB
Popis:	Nowadays we use multiple molecular typing methods capable of distinguishing bacteria strains. However, a majority of these methods are time-consuming, and associated costs are not negligible. Also, reproducibility of typing results is questionable. Therefore, we propose new typing methodology based on bioinformatics. In this paper, we present an algorithm that is at the core of the new method. It consists of multiple steps, such as measuring the quality of input data, identification of genes having high diversity and analysis of results employing clustering and phylogenetic trees. Obtained results are then compared with results from the mini-MLST method.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c19a17258452114a3f8d84896c6402af https://doi.org/10.1007/978-3-319-91211-0_37 Zobrazit plný text záznamu