New arylhexahydropyrimidinediones: Synthesis, benzodiazepine receptor affinity and anticonvulsant activity

Autor:	Patrick Dallemagne, Jean Guillon, M. A. Quermonne, E. Legrand, Michel Boulouard, D. Radulovic, Max Robba, Martine Daoust, Sylvain Rault
Rok vydání:	1996
Předmět:	Pharmacology Benzodiazepine Stereochemistry Chemistry medicine.drug_class medicine.medical_treatment Organic Chemistry General Medicine Ligand (biochemistry) Chemical synthesis chemistry.chemical_compound Anticonvulsant Drug Discovery Benzene derivatives medicine Lactam Receptor
Zdroj:	European Journal of Medicinal Chemistry. 31:335-339
ISSN:	0223-5234
DOI:	10.1016/0223-5234(96)80371-0
Popis:	Summary Synthesis of new 3-alkyl-6-arylhexahydropyrimidine-2,4-dione derivatives was achieved starting from various benzaldehydes. Their affinity towards the benzodiazepine receptor and their anticonvulsant effect were evaluated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c18a78fa8dbd93c02a501f14e533d016 https://doi.org/10.1016/0223-5234(96)80371-0 Zobrazit plný text záznamu Full Text from ScienceDirect