Fabrication and in vitro analysis of tubular scaffolds by melt-drawing for esophageal tissue engineering

Autor:	Yu Jun Tan, Xipeng Tan, Kah Fai Leong, Jia An, Kerm Sin Chian, Wai Yee Yeong
Rok vydání:	2015
Předmět:	Scaffold Materials science Fabrication business.product_category Mechanical Engineering Condensed Matter Physics Esophageal Tissue In vitro analysis Tissue engineering Mechanics of Materials Ultimate tensile strength Microfiber General Materials Science Composite material Cell adhesion business
Zdroj:	Materials Letters. 159:424-427
ISSN:	0167-577X
Popis:	A highly aligned microfibrous tubular scaffold was developed for esophageal tissue engineering, aiming to fabricate a biomechanically compatible esophageal scaffold. The tubular scaffold was fabricated by melt-drawing of poly( l -lactide-co-ɛ-caprolactone) (PLC). Different melt-drawing speeds were evaluated in order to obtain an optimal microfiber dimension for the scaffold. Preliminary tensile results show that these scaffolds have comparable tensile properties with the native esophagus. All the scaffolds were found to promote cell adhesion and proliferation based on the in vitro results. It suggests that the melt-drawn PLC tubular scaffold with an autologous cell-seeding could be a good candidate for the esophageal tissue engineering.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c18722df3075060d09fde264519851b3 https://doi.org/10.1016/j.matlet.2015.07.061 Zobrazit plný text záznamu Full Text from ScienceDirect