Estimation of events of hair follicle layers differentiation
| Autor: | I. F. Latypov, A. S. Musaeva, E. B. Vsevolodov, Yu. K. Doronin, V. A. Golichenkov |
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| Rok vydání: | 2015 |
| Předmět: |
integumentary system
Experimental model Anatomy Root sheath Biology Hair follicle General Biochemistry Genetics and Molecular Biology Follicle medicine.anatomical_structure otorhinolaryngologic diseases medicine Biophysics sense organs Cambium General Agricultural and Biological Sciences Concentration gradient Developmental biology General Environmental Science Cuticle (hair) |
| Zdroj: | Moscow University Biological Sciences Bulletin. 70:62-66 |
| ISSN: | 1934-791X 0096-3925 |
| DOI: | 10.3103/s009639251502008x |
| Popis: | Correlation and regression analysis of morphogenetic relationships between the hair crosssection diameter and parameters of other layers of the hair follicle was performed. On the basis of these data, a computer model of the hair follicle was developed, which, after entering the hair diameter or the crosssection area makes it possible to obtain data on corresponding parameters of other layers of the hair follicle and their proportions. A model of induction of different layers of the hair follicle in the stable hairgrowth phase (anagen VI) is proposed, which is ensured by different concentration ranges of the main inductor (arranged as a concentration gradient from the follicle axis towards its periphery), which is produced by the cambium or connectivetissue papilla. According to this model, the induction of some layers requires three additional contact actions of approximal layers: (1) outer sheath → Henle layer, (2) inner sheath → hair cuticle, and (3) hair cuticle → inner sheath cuticle. The results extend the possibility of using the hair follicles as an experimental model in developmental biology. |
| Databáze: | OpenAIRE |
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