Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Novel Indoline Derivatives

Autor:	dhinesh kumar manoharan
Rok vydání:	2016
Předmět:	chemistry.chemical_compound Chemistry Stereochemistry medicine.drug_class Indoline medicine Organic chemistry IC50 In vitro Anti-inflammatory
Zdroj:	JOURNAL OF ADVANCES IN CHEMISTRY. 12:4557-4563
ISSN:	2321-807X
DOI:	10.24297/jac.v12i12.4826
Popis:	Series of indoline derivatives were synthesized using N-(4-aminophenyl) indoline-1-carbothiamide as a precursor. The structures of synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR and LC-MS. The in vitro anti-inflammatory activity of synthesized indoline derivatives were examined by standard anti-denaturation assay. The compounds 4a (IC50 = 62.2 µg/ml) and 4b (IC50 = 60.7 µg/ml) showed potent inhibition on protein denaturation. The compounds 5a (IC50 = 97.8 µg/ml) exhibits moderate inhibition on protein denaturation
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c178ee826c13c80c786a95f92f910b49 https://doi.org/10.24297/jac.v12i12.4826 Zobrazit plný text záznamu