Analysis of distribution of chromatin marks across 'divergence islands' in three-spined stickleback (Gasterosteus aculeatus)
| Autor: | Alexey E. Sokolov, Egor Prokhortchouk, Alexander Mazur, Sergey M. Rastorguev, Svetlana Zhenilo |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
General Immunology and Microbiology biology Three-spined stickleback Zoology Stickleback General Medicine Gasterosteus biology.organism_classification General Biochemistry Genetics and Molecular Biology Chromatin 03 medical and health sciences 030104 developmental biology Evolutionary biology H3K4me3 Epigenetics General Pharmacology Toxicology and Pharmaceutics Adaptation Enhancer |
| Zdroj: | F1000Research. 5:2880 |
| ISSN: | 2046-1402 |
| DOI: | 10.12688/f1000research.10428.1 |
| Popis: | The three-spined stickleback (Gasterosteus aculeatus) is a well-known model organism for studying adaptations to water salinity. In this work, we investigate the dynamics of an epigenetic landscape of water salinity adaptation using three chromatin marks: H3K27ac, H3K4me1 and H3K4me3. The choice of marks was determined by the fact that some adaptive genomic loci are situated in gene-free regions, suggesting their regulatory role as enhancers. Histone modifications seem to be a promising mechanism that could regulate such regions. Difference between histone modifications in sea and freshwater - both in genes and intergenic enhancers - may contribute to epigenetic plasticity of stickleback adaptation. As a result of this study, we found differential chromatin peaks in "divergence islands" at enhancer elements and promoters of genes, which are responsible for stress adaptation and homeostasis. However, a full genome study analysis is required to fully understand mechanism of adaptation to water salinity. |
| Databáze: | OpenAIRE |
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