The new trend in the treatment of experimental cryptosporidiosis and the resulting intestinal dysplasia

Autor:	Eman M. Fawzy, Hayam E. Rashed, Enas F. Abdel Hamed, Salem Y Mohamed, Nahed E Mostafa, Rabab S Zalat
Rok vydání:	2018
Předmět:	0301 basic medicine Intestinal Dysplasia medicine.medical_specialty Colorectal cancer business.industry Gastroenterology medicine.disease 03 medical and health sciences 030104 developmental biology Oncology Internal medicine medicine business
Zdroj:	Colorectal Cancer. 7:CRC06
ISSN:	1758-1958 1758-194X
Popis:	Aim: Cryptosporidiosis causes colon dysplasia. This research aimed to evaluate the effect of a novel combination between artesunate and nitazoxanide on intensity of infection and the resulting intestinal dysplasia. Materials & methods: Subjects were divided into five groups. Artesunate was used alone, then combined with nitazoxanide. Results: The highest efficacy in reducing oocyst shedding obtained from the combined therapy (68.5, 75.9, 99%) after 7, 14 and 21 days. The histopathology of infected colonic mucosa showed marked improvement and low-grade of dysplasia in the infected and treated group with the combined therapy. The immunohistochemistry of the same group revealed mild dysplastic changes in colonic epithelium without nuclear expression for cyclin D1. Conclusion: These results give hope for treatment of Cryptosporidium and improving intestinal dysplasia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c1709b1f9bdf241da610dcc4efb6e3ed https://doi.org/10.2217/crc-2018-0008 Zobrazit plný text záznamu