The effects of a linear increase in dietary indole glucosinolates on growth and physiology of mice
| Autor: | C. S. Darroch, J. M. Bell, J. H. L. Mills, D. I. McGREGOR |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Indole test
medicine.medical_specialty Kidney Food intake Ratón Liver and kidney Biology biology.organism_classification medicine.anatomical_structure Endocrinology Food Animals Internal medicine Toxicity medicine Brassica oleracea lipids (amino acids peptides and proteins) Animal Science and Zoology Compensatory growth (organism) Food science |
| Zdroj: | Canadian Journal of Animal Science. 71:887-896 |
| ISSN: | 1918-1825 0008-3984 |
| DOI: | 10.4141/cjas91-104 |
| Popis: | An extract of indole glucosinolates (GSLs) isolated from Brussels sprouts (Brassica oleracea) was incorporated into semipurified diets to study the effects of indole GSLs on growth, feed mtake and thyroid, liver and kidney function over a 16-d period. Increasing levels (0.2–8.2 μmol g−1 DM) of dietary indole GSLs, primarily indolyl-3-methyl-GSL, decreased feed intakes of mice linearly (P −1 DM) of indole GSLs but mice adapted to their presence and this was reflected by compensatory growth. Feed intakes of mice fed diets containing 8.2 μmol indole GSLs g−1 DM were lowered dramatically which resulted in an increase in mortality. Mortality may have resulted from a toxic effect of indolyl-3-methyl-GSL or indoleacetonitrile but was most likely a result of starvation. Indole GSLs from the extract were not goitrogenic and had no apparent effect on thyroid, hepatic or renal weights or morphology. It was concluded that dietary indole GSLs, primarily indolyl-3-methyl-GSL, below 3 μmole g−1 DM did not adversely affect growth performance in mice and may have contributed to a small improvement in feed efficiency. Key words: Indole glucosinolates, growth, feeding value, mice |
| Databáze: | OpenAIRE |
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