Detection of benzylpenicillin sodium and ampicillin residue based on flower-like silver nanostructures using surface-enhanced Raman spectroscopy

Autor: Hualan Zhou, Jianguo Zhang, Yingfang Liang, Feng Wang
Rok vydání: 2021
Předmět:
Zdroj: Research on Chemical Intermediates. 48:117-128
ISSN: 1568-5675
0922-6168
DOI: 10.1007/s11164-021-04574-9
Popis: The capability to evaluate antibiotic residues in a sensitive, rapid, and reliable manner, is of great importance. Surface-enhanced Raman spectroscopy (SERS) is the phenomenon related to rough surface, which is used to effectively detect residual antibiotics in food. In this work, SERS strategy was used for the determination of antibiotic Benzylpenicillin sodium (NaBP) and Ampicillin (AMP) in the milk based on flower-like Ag nanoparticles, synthesized at 25 °C. A liner correlation was twigged between the SERS signal and the concentration for NaBP and AMP, with regression coefficient of 0.997 and 0.987. The limit of detection of NaBP and AMP residue based on this SERS-based detection, can be as low as 6.3 × 10–9 mol L−1 and 9.2 × 10–10 mol L−1, respectively. The presented method can be used for the determination of NaBP and AMP residue in milk. The recovery is 83–95% and 80–96%, and the relative standard deviation is 4.7–8.5% and 5.3–15.1%, respectively, which could be a simple method for the determination of antibiotic residues in animal derived food.
Databáze: OpenAIRE
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