n-Heptane ��� Addendum: evaluation of a BAT value
| Autor: | Ro��bach, Bernd, Drexler, Hans, Hartwig, Andrea, MAK Commission |
|---|---|
| Jazyk: | němčina |
| Rok vydání: | 2021 |
| Předmět: |
3-Heptylalkohol
biological tolerance value BAT value 3-heptanol heptane-3-ol ethyl butyl carbinol Heptan-3-ol 2 5-heptanedione 2-heptanol Biologischer-Arbeitsstoff-Toleranzwert 2-Heptylalkohol n-Heptan n-heptane 3-heptyl alcohol heptane-2 5-dione 2 5-Heptandion methyl amyl carbinol dipropylmethane Ethylbutylcarbinol urine Heptan-2-ol Heptan-2 5-dion heptane-2-ol 2-heptyl alcohol Dipropylmethan BAT-Wert Amylmethylcarbinol |
| DOI: | 10.34865/bb14282e6_4ad |
| Popis: | The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated n-heptane [142-82-5] in 2020 and derived a biological tolerance value (BAT value) considering heptane-2,5-dione in urine to characterise the internal exposure. The BAT value is based on the correlation between external and internal exposure and represents an equivalent of the maximum workplace concentration (MAK value) of n-heptane in biological material, taking into account central nervous effects and peripheral neurotoxicity as critical systemic effects. Mainly data from two human experimental exposure studies were used to derive the BAT value. In a more recent study, 20 non-smoking volunteers were exposed at rest to n-heptane up to 500 ml/m3. Data on renal excretion of the n-heptane metabolite heptane-2,5-dione were similar to those obtained by another working group. The few available workplace studies were not suitable to derive a BAT value. An analysis of the pooled data from both experimental studies resulted in an extrapolated urinary concentration of 235 ��g heptane-2,5-dione/l urine after eight hours of exposure to the current MAK value of 500 ml/m3. Due to a blood/air partition coefficient |
| Databáze: | OpenAIRE |
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