Oxygenation within the first 120 h following coronary artery bypass grafting. Influence of systemic hypothermia (32 °C) or normothermia (36 °C) during the cardiopulmonary bypass: a randomized clinical trial
| Autor: | David Murley, J. Sollid, S. Kjærgaard, Egon Toft, Bodil Steen Rasmussen, Stephen Edward Rees |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
business.industry General Medicine Oxygenation Hypothermia Cardiac surgery law.invention Coronary artery bypass surgery surgical procedures operative Anesthesiology and Pain Medicine medicine.anatomical_structure law Anesthesia Internal medicine medicine Cardiology Cardiopulmonary bypass medicine.symptom Complication business Shunt (electrical) circulatory and respiratory physiology Artery |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 50:64-71 |
| ISSN: | 0001-5172 |
| DOI: | 10.1111/j.1399-6576.2006.00897.x |
| Popis: | Background: Lung function is often impaired after cardiac surgery performed under cardiopulmonary bypass (CPB). Normothermic CPB has become more common, but it remains unknown whether it reduces post-operative lung function compared with hypothermic CPB. The aim of this study was to investigate oxygenation within the first 120 h after systemic hypothermia and normothermia under CPB. Methods: Thirty patients undergoing coronary artery bypass grafting (CABG) were randomized to either hypothermic (32 °C) or normothermic (36 °C) CPB. Oxygenation was studied by a simple method for the estimation of intrapulmonary shunt and ventilation–perfusion (V/Q) mismatch pre-operatively and 4, 48 and 120 h post-operatively by changing Fio2 in four to six steps. V/Q mismatch was described with ΔPo2 (normal values, 0–2.38 kPa). Results: Shunt and V/Q mismatch (ΔPo2) increased post-operatively in both groups (P |
| Databáze: | OpenAIRE |
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