Development of a Scalable Synthesis of the Small Molecule TGFβR1 Inhibitor BMS-986260

Autor:	David K. Leahy, Martin D. Eastgate, Arvind Mathur, Richard Rampulla, Varadharajan Subramanian, Upender Velaparthi, Sathishkumar Chandrasekaran, Karthikeyan Chinnakalai, Arun Kumar Gupta, Antony Savarimuthu, Thirumalai Lakshminarasimhan, Souvik Rakshit, Indasi Gopikumar, Jayakumar Sankara Warrier, Chetan Padmakar Darne, Robert M. Borzilleri, Rajappa Vaidyanathan, Anuradha Gupta, Ananta Karmakar, Vignesh Radhakrishnan, Muthalagu Vetrichelvan, Dyamanna Doddalingappa, Senthil Palani
Rok vydání:	2020
Předmět:	stomatognathic diseases chemistry.chemical_compound Column chromatography chemistry digestive oral and skin physiology Organic Chemistry TosMIC Physical and Theoretical Chemistry Combinatorial chemistry Small molecule
Zdroj:	Organic Process Research & Development. 24:1310-1320
ISSN:	1520-586X 1083-6160
Popis:	A scalable route to the small molecule TGFβR1 inhibitor BMS-986260 (1) was developed. This alternative approach circumvented the purification of intermediates by column chromatography and provided ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c1479cf30ab1db39b487237c60ba0c40 https://doi.org/10.1021/acs.oprd.0c00232 Zobrazit plný text záznamu