Spectrum of Acute Kidney Injury in Pregnancy associated Thrombotic Microangiopathy
| Autor: | S Rajendiran, M Jayakumar, G Barathi, Pradnya V Manglekar, Subalakshmi Balasubramanian |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Pregnancy Thrombotic microangiopathy Abnormal platelet aggregation Microvascular thrombosis business.industry Microangiopathy 030232 urology & nephrology Acute kidney injury Thrombotic thrombocytopenic purpura 030204 cardiovascular system & hematology urologic and male genital diseases medicine.disease Gastroenterology female genital diseases and pregnancy complications 03 medical and health sciences 0302 clinical medicine Renal cortical necrosis hemic and lymphatic diseases Internal medicine medicine business |
| Zdroj: | IP Journal of Diagnostic Pathology and Oncology. 5:339-343 |
| ISSN: | 2581-3706 2581-3714 |
| DOI: | 10.18231/j.jdpo.2020.066 |
| Popis: | Thrombotic microangiopathy (TMA) is characterized by microvascular thrombosis due to endothelial injury or abnormal platelet aggregation. It commonly manifests as microangiopathic hemolytic anaemia, thrombocytopenia and organ injury that may include acute kidney injury (AKI). It has a diverse etiology. Pregnancy associated TMA represents a secondary form that may be caused by complement mediated Hemolytic Uremic Syndrome (HUS), Thrombotic Thrombocytopenic Purpura (TTP) and preeclampsiaeclampsia, Rarely, renal cortical necrosis – a catastrophic event, may be seen in pregnancy-related TMA. We discuss three cases of thrombotic microangiopathy related to pregnancy. TMA is associated with significant fetomaternal morbidity and mortality and hence a rapid diagnosis and prompt disease management is crucial for a favourable patient outcome. Keywords: AKI, Pregnancy, Thrombotic microangiopathy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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