Prevention of Apnea and Bradycardia in Low-Birthweight Infants
| Autor: | Daniel C. Shannon, Felicita Gotay, Israel M. Stein, Mark C. Rogers, I. David Todres, Fergus M.B. Moylan |
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| Rok vydání: | 1975 |
| Předmět: | |
| Zdroj: | Pediatrics. 55:589-594 |
| ISSN: | 1098-4275 0031-4005 |
| Popis: | The efficacy of theophylline in preventing severe apnea was evaluated in 17 low-birthweight infants (mean weight, 1,400 gm). Apnea was detected and accurately quantified by 13-hour pneumogram recordings and correlated with serum theophylline levels. Nursing observations coupled with on-line alarm systems detected only 39% of severe apneic episodes as compared to the pneumogram recording technique. Theophylline in six hourly oral doses (1.5 to 4.0 mg/kg) yielded two-hour serum concentrations of 6.6 to 11.Oµg/ml which completely controlled apneic spells exceeding 20 seconds in duration and markedly reduced 10- 19-second apneic episodes and any resultant bradycardia. At these serum levels, toxicity was not observed. Therapy with theophylline should be instituted at a dose of 2 to 3 mg/kg every six hours and the optimum therapeutic dose should be individualized as determined by objective quantitation of apnea and serum theophylline concentration. |
| Databáze: | OpenAIRE |
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