Abstract 403: Metabolic Characteristics of Spontaneously Hypertensive Rats Compared With Normotensive Controls

Autor:	Jaime Clark, Peter Zahradka, Carla Taylor
Rok vydání:	2014
Předmět:	Cardiology and Cardiovascular Medicine
Zdroj:	Arteriosclerosis, Thrombosis, and Vascular Biology. 34
ISSN:	1524-4636 1079-5642
Popis:	Objectives: To differentiate the metabolic responses of spontaneously hypertensive rats (SHR) compared to normotensive Wistar Kyoto (WKY) rats. Methods: Blood pressure and pulse wave velocity (PWV) measurements were conducted on 25 week old SHR and WKY rats. At the time of termination, vital organs were harvested and weighed, and serum was collected for analysis of blood lipids, liver enzymes, and urea levels. Results: SHR exhibited higher readings for mean arterial pressure (MAP) (p< 0.0001), peak velocity (PWV) (p=0.017), heart/body weight (BW) ratio (p Conclusion: The positive relationship between serum AST and left ventricular wall/BW ratio, but not liver/BW ratio, suggests a possible response to changes in cardiac muscle, independent of blood pressure. Serum urea levels responded to MAP and heart/BW ratio. These metabolic responses of SHR compared to WKY invite further investigation of possible mechanisms underlying the link with cardiovascular dysfunction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c1248c7c6535cc3bf95182da5797f2da https://doi.org/10.1161/atvb.34.suppl_1.403 Zobrazit plný text záznamu