Non-invasive continuous renal tissue oxygenation monitoring to identify preterm neonates at risk for acute kidney injury

Autor: Claudette O. Adegboro, Luke J. Richard, Ryan M. McAdams, Matthew W. Harer
Rok vydání: 2021
Předmět:
Zdroj: Pediatric Nephrology. 36:1617-1625
ISSN: 1432-198X
0931-041X
DOI: 10.1007/s00467-020-04855-2
Popis: Near-infrared spectroscopy (NIRS) is an emerging tool to identify signs of inadequate tissue oxygenation in preterm neonates with acute kidney injury (AKI). Previous studies have shown a correlation between low renal tissue oxygenation (RrSO2) in the first 24 hours of age and the later development of AKI. In this prospective clinical trial, NIRS monitoring was used to identify changes in RrSO2 in comparison to traditional AKI markers, serum creatinine (SCr), and urine output (UOP). We enrolled 35 preterm neonates born less than 32 weeks’ gestation and applied neonatal NIRS sensors at less than 48 hours of age. Neonates underwent 7 days of continuous monitoring. Renal and demographic information were collected for the first 7 days of age. AKI was determined by the modified neonatal Kidney Disease: Improving Global Outcomes (KDIGO) definition including UOP. Three patients experienced AKI, all based on both SCr and UOP criteria. Each neonate with AKI had decreases in RrSO2 over 48 hours prior to changes in SCr and UOP. Patients with AKI had lower median RrSO2 values compared to patients without AKI over the first week of age, (32.4% vs. 60%, p
Databáze: OpenAIRE
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