ChemInform Abstract: Enantioselective Copper-Catalyzed Conjugate Addition of Diethylzinc to Enones Using New Chiral P,N Ligands Composed of (S)-2-Alkyl-2-aminoethylphosphines and α-Substituted Pyridines

Autor:	Akihito Saitoh, Masato Suzuki, Yoichi Yamaguchi, Toshiaki Morimoto
Rok vydání:	2001
Předmět:	chemistry.chemical_classification Chalcone chemistry.chemical_compound chemistry Stereochemistry Cyclohexenone Ligand Copper catalyzed Enantioselective synthesis General Medicine Diethylzinc Alkyl Conjugate
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
Popis:	New P,N ligands prepared from (S)-2-alkyl-2-aminoethylphosphines and α-substituted pyridines are efficient chiral ligands for the copper-catalyzed conjugate addition of diethylzinc to 2-cyclohexen-1-one and chalcone. The best result (90–91% ee) for the cyclohexenone was obtained with Cu(OTf)2 (0.7–1 mol%) and a P,N ligand 4 derived from (S)-1-(diphenylphosphino)-3-methyl-2-butanamine and 6-methylpyridine-2-carboxaldehyde.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c1149dc333d46ead163d03e21cebecff https://doi.org/10.1002/chin.200111078 Zobrazit plný text záznamu Plný text