FUNCTION AND MECHANISM OF ANGIOTENSIN-CONVERTING ENZYME-2 RECEPTOR TO TRANSPORT SARS-COV-2 INTO THE HOST CELLS―A REVIEW
| Autor: | Rabia Sultan, Nimra Sardar, Sarmad Ahmad Qamar, Wajiha Akmal, Muhammad Sarfaraz Iqbal, Muhammad Husnain Iqbal, Muhammad Bilal |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
General Veterinary
viruses 030231 tropical medicine Cell Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Virus Release Virus Cell biology Pathogenesis 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Viral entry medicine 030212 general & internal medicine General Agricultural and Biological Sciences Receptor Intracellular Coronavirus |
| Zdroj: | Journal of Experimental Biology and Agricultural Sciences. 8:S190-S201 |
| ISSN: | 2320-8694 |
| DOI: | 10.18006/2020.8(spl-1-sars-cov-2).s190.s201 |
| Popis: | Novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly spread across the world SARS-CoV-2 is viewed as a continuous global health threat resulting in an alarming number of fatalities worldwide Angiotensin-converting enzyme-2 (ACE2) has been recognized as one of the vital receptors for the SARS-CoV-2, leading to viral entry into the host cells It also helps many other receptors, which initiate the entry of SARS-CoV-2 in the host body A variety of proteins and enzymes are involved in triggering the transport mechanism The route of viral infection depends on the distribution and expression of receptors, as the virus reaches the cell by binding to cell receptors to complete intracellular replication, virus release, and cause cytotoxicity In addition to alveolar lung tissues, ACE2 also plays a pivotal role in other organs Due to the abundant presence in lung cells, SARS-CoV-2 mostly affects the lungs and causes their destruction The spike protein utilizes the digestion of ACE2, which strongly contributes to the pathogenesis of severe lung failure Different experiments show that ACE2 not only helps the virus to migrate in the host cell but also allow us to fight against this pandemic disease This review article summarizes the current progress that highlights the critical biological functionalities and mechanisms of ACE2 as the novel receptor to transport SARS-CoV-2 into host cells matrix © 2020, Editorial board of Journal of Experimental Biology and Agricultural Sciences All rights reserved |
| Databáze: | OpenAIRE |
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