| Předmět: |
Suberea ianthelliformis
biology 010405 organic chemistry Pharmaceutical Science biology.organism_classification 01 natural sciences Acetylcholinesterase 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Sponge chemistry Biochemistry Drug Discovery Ic50 values Tyrosine Cancer cell lines Psammaplysene D Cytotoxicity Pharmacology Toxicology and Pharmaceutics (miscellaneous) |
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| Zdroj: | Marine Drugs. |
| ISSN: | 1660-3397 |
| Popis: | Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC50 values of 0.7 μM and 1.3 μM, respectively. |
| Databáze: | OpenAIRE |
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