Evaluation of the Anti-inflammatory Properties ofChlorophora excelsa. Stem Bark Extract

Autor:	Olumayokun A. Olajide, Oyetunji T. Kolawole, Temitope R. Fagbohun, Franklin F. Ajayi
Rok vydání:	2005
Předmět:	Pharmacology Traditional medicine medicine.drug_class business.industry Pharmaceutical Science Inflammation General Medicine Pharmacognosy medicine.disease Anti-inflammatory Complementary and alternative medicine Pedal Edema Granuloma visual_art Edema Drug Discovery medicine visual_art.visual_art_medium Molecular Medicine Croton oil Bark medicine.symptom business
Zdroj:	Pharmaceutical Biology. 43:746-748
ISSN:	1744-5116 1388-0209
DOI:	10.1080/13880200500406388
Popis:	A methanol extract of the stem bark of Chlorophora excelsa. (Welw.) Benth and Hook was evaluated for anti-inflammatory activity in different models. Acute inflammatory effects were studied in the carrageenan-induced rat paw edema, and the effect of the extract in chronic inflammation was evaluated using the cotton pellet granuloma test. The effect of the extract on topical inflammation induced with croton oil was also tested in mice. The extract produced a significant (p < 0.05) and dose-dependent inhibition of the carrageenan-induced pedal edema, as well as granuloma tissue formation in rats. Topical anti-inflammatory effect was only evident with 400 mg/kg of the extract. This study demonstrated acute, chronic, and topical anti-inflammatory properties of the methanol extract of C. excelsa..
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c0ff09bedfe8635b0260a710263bba83 https://doi.org/10.1080/13880200500406388 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.