Immediate Release of Prolactin and Biphasic Effects on Growth Hormone Release Following Electrical Stimulation of the Median Eminence1

Autor:	P. V. Malven
Rok vydání:	1975
Předmět:	medicine.medical_specialty Chemistry Endogeny Stimulation Growth hormone Prolactin Somatropin Endocrinology Hypothalamus Internal medicine Median eminence medicine Immediate release
Zdroj:	Endocrinology. 97:808-815
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-97-4-808
Popis:	The median eminence (ME) region of the hypothalamus was electrically stimulated through permanently implanted electrodes in 4 unanesthetized sheep. Plasma concentrations of GH and prolactin (PRL) were measured at 10-min intervals before, during and after 30-min periods of electrical stimulation or sham procedures. The onset of ME stimulation decreased plasma GH in all 17 cases in which prestimulation GH levels were 1.0 ng⁄ml or higher. In all 27 cases of ME stimulation, plasma GH never increased during the 30-min stimulation period. However, spontaneous GH increases were noted during sham procedures in 9 of 31 cases. The termination of ME stimulation was followed within 10–20 min by markedly increased GH levels in 24 of 27 cases. All 4 ewes responded to electrical stimulation with comparable biphasic effects on GH release even though electrode locations varied slightly. These results indicate localization and stimulationinduced release of endogenous neurohormones in the ME region with activities inhibitin...
Databáze:	OpenAIRE
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