Long term treadmill exercise affects age-related oxidative stress in the spinal cord of rats
| Autor: | Ghaffar Shokouhi, Farzam Sheikhzadeh, Nasser Ahmadiasl, Leila Roshangar, Amir Ghorbanihaghjo, Morteza Kosari-Nasab, Mehran Mesgari |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Antioxidant Physiology Veterinary (miscellaneous) Endocrinology Diabetes and Metabolism medicine.medical_treatment Biophysics Treadmill exercise medicine.disease_cause Biochemistry 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine Age related medicine Orthopedics and Sports Medicine 030304 developmental biology chemistry.chemical_classification 0303 health sciences Reactive oxygen species business.industry Spinal cord Endocrinology medicine.anatomical_structure chemistry Apoptosis business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Comparative Exercise Physiology. 17:373-379 |
| ISSN: | 1755-2559 1755-2540 |
| DOI: | 10.3920/cep200031 |
| Popis: | Age-induced apoptosis is believed to be caused by the imbalance between production of reactive oxygen species (ROS) and human body antioxidant defence. Regular aerobic treadmill-exercise has been suggested to enhance the antioxidant defence. This study aimed to investigate the effects of long-term treadmill exercise on age-related oxidative stress and the apoptosis of oligodendrocytes in the spinal cord of the rat. Sixty male rats were divided into six groups: three exercised groups, which underwent 6, 9 and 12 months of mild-to-moderate treadmill exercise and three non-exercised control groups. Spinal cord white or grey matter tissue sampling was done through mid-thoracic laminectomy. The malondialdehyde (MDA; indicator of oxidative stress) levels, the number of apoptotic oligodendrocytes and ultrastructural alterations were also evaluated. Our data showed that treadmill exercise resulted in decreased lipid peroxidation and the number of apoptotic oligodendrocytes in the spinal cord of rats, as compared to non-exercised animals. These results were confirmed by TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labelling) staining and electron microscope. This study suggests that the long-term treadmill exercise can affect oxidative stress and oligodendrocytes apoptosis in the spinal cord of aged rats and further studies are needed to validate these findings in humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|