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BackgroundPatient-reported outcome measures (PROM) have been shown to have important prognostic value after various cardiac interventions. We assessed the association between the change in Kansas City Cardiomyopathy Questionnaire 12 (KCCQ-12) score after transcatheter aortic valve replacement (TAVR) and mortality.MethodsWe included patients who underwent TAVR at Mayo Clinic between February 2012, and June 2022, who completed KCCQ-12 prior to and 30-45 days after the procedure. Patients were categorized into 3 groups: those who experienced significant (≥ 19 points;group-1), modest (1-19 points;group-2), and no improvement (≤ 0 points;group-3).ResultsA total of 1,124 patients were included: 60.8% males; 97.6% Caucasian. Mean age was 79.4±8.3 years, KCCQ-12 score was 53.9±24.5, and median STS score was 4.9% (interquartile range 3.1-8.0). At 45 days, the mean change in KCCQ-12 score was 19±24 points: 46.3% (n= 520) of patients had a significant improvement in their KCCQ-12 score, while 33.4% (n= 375) and 20.4% (n = 229) had modest and no improvement, respectively. Median survival was higher in group-1 (5.7±0.2 years) compared to groups 2 and 3 (5.1±0.3 and 4.1±0.4 years, respectively;PConclusionPatients who experience modest or no improvement in KCCQ-12 score after TAVR have substantially higher long-term mortality. Delta KCCQ-12 is a cost-effective, efficient tool that can identify patients at increased risk of death at long-term follow-up post-TAVR.Clinical PerspectiveWhat is New?This study documents the prognostic value of the Kansas City Cardiomyopathy Questionnaire 12 score in predicting long-term survival after TAVR.Modest or no improvement in the Kansas City Cardiomyopathy Questionnaire 12 score after TAVR is associated with a considerably higher long-term mortality risk.What are the Clinical Implications?Changes in the Kansas City Cardiomyopathy Questionnaire 12 score may identify patients with higher residual mortality risk after transcatheter aortic valve replacement. |
