Native California soils are selective reservoirs for multidrug-resistant bacteria
| Autor: | Amanda C. Hollowell, Nathaniel Gleason, Joel L. Sachs, John U. Regus, Kelsey A. Gano, Victor J. Pahua, Stefanie Graeter, Kareem Shahin, Gabriel Lopez |
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| Rok vydání: | 2015 |
| Předmět: |
0303 health sciences
biology Resistance (ecology) 030306 microbiology Host (biology) Ecology Lineage (evolution) food and beverages Drug resistance 15. Life on land biology.organism_classification Agricultural and Biological Sciences (miscellaneous) Bradyrhizobium Multiple drug resistance 03 medical and health sciences Antibiotic resistance Soil microbiology Ecology Evolution Behavior and Systematics 030304 developmental biology |
| Zdroj: | Environmental Microbiology Reports. 7:442-449 |
| ISSN: | 1758-2229 |
| DOI: | 10.1111/1758-2229.12269 |
| Popis: | Soil bacteria can exhibit extensive antibiotic resistomes and act as reservoirs of important antibiotic resistance traits. However, the geographic sources and evolutionary drivers of resistance traits are poorly understood in these natural settings. We investigated the prevalence, spatial structure and evolutionary drivers of multidrug resistance in natural populations of Bradyrhizobium, a cosmopolitan bacterial lineage that thrives in soil and aquatic systems as well as in plant and human hosts. We genotyped > 400 isolates from plant roots and soils across California and assayed 98 of them for resistance traits against 17 clinically relevant antibiotics. We investigated the geographic and phylogenetic structure of resistance traits, and analysed correlations of resistance with strain abundance, host infection capacity and in vitro fitness. We found: (i) multidrug resistance at all sites, (ii) subsets of resistance traits that are spatially structured and (iii) significant associations between resistance traits and increased strain abundance or host infection capacity. Our results highlight multiple selective factors that can result in the spread of resistance traits in native Bradyrhizobium populations. |
| Databáze: | OpenAIRE |
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