Key steps and intermediates in the catalytic mechanism for the reduction of peroxides by the antioxidant ebselen
| Autor: | Kai N. Sands, Thomas G. Back |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Antioxidant 010405 organic chemistry Cellular respiration Ebselen Glutathione peroxidase medicine.medical_treatment Organic Chemistry Glutathione 010402 general chemistry medicine.disease_cause 01 natural sciences Biochemistry 3. Good health 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Drug Discovery medicine Hydrogen peroxide Oxidative stress |
| Zdroj: | Tetrahedron. 74:4959-4967 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2018.05.027 |
| Popis: | Hydrogen peroxide and lipid hydroperoxides are formed during aerobic metabolism and contribute to oxidative stress, a major factor in many diseases and degenerative conditions. Although the selenoenzyme glutathione peroxidase (GPx) affords antioxidant protection in vivo by catalytically reducing harmful peroxides with glutathione, certain conditions benefit from the administration of small-molecule GPx mimetics for additional protection. To date, ebselen has been the most widely studied such compound, but its catalytic mechanism is complex and highly variable with conditions. Progress in elucidating the mechanistic details of its antioxidant activity is described in this review. |
| Databáze: | OpenAIRE |
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