An Analysis of the Associations of Polymorphic Variants of the LEPR (rs1137100), LRP5 (rs3736228), and LPL (rs320) Genes with the Risk of Developing Type 2 Diabetes Mellitus
Autor: | Olga E. Mustafina, L. Z. Akhmadishina, L. F. Sharipova, T. V. Morugova, O. V. Kochetova, Gulnaz F. Korytina, D. S. Avzaletdinova |
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Rok vydání: | 2019 |
Předmět: |
0106 biological sciences
0303 health sciences medicine.medical_specialty Type 2 Diabetes Mellitus Locus (genetics) Type 2 diabetes Biology medicine.disease 01 natural sciences Obesity 03 medical and health sciences Endocrinology Internal medicine Diabetes mellitus Genotype Genetics medicine Allele Body mass index 030304 developmental biology 010606 plant biology & botany |
Zdroj: | Russian Journal of Genetics. 55:495-503 |
ISSN: | 1608-3369 1022-7954 |
Popis: | Diabetes mellitus is a hereditary predisposed multifactorial disease. However, the genetic mechanisms of its development have not been fully revealed yet. We conducted a search for associations of polymorphic variants of the LEPR (rs1137100), LRP5 (rs3736228), and LPL (rs320) genes involved in the development of obesity with the development of type 2 diabetes mellitus. The association with development of the disease was established for the T allele of the LRP5 locus (rs3736228) (p = 0.029, OR = 1.46). The rs1137100 locus (p = 0.032) of the LEPR gene was shown to be associated with the body mass index (BMI), but it was not connected with the presence of type 2 diabetes mellitus. Risk markers of development of type 2 diabetes included the T allele of the rs3736228 locus of the LRP5 gene (OR = 1.74, p = 0.012) and the G allele of the rs320 locus of the LPL gene (OR = 1.39, p = 0.027). Statistically significant association was only found in the group of nonobese patients. A decrease in the level of low-density lipoprotein was observed in individuals with the TT genotype of the LPL locus (rs320) (p = 0.04). Individuals with the GT and GG genotypes of this locus had a lower cholesterol level (p = 0.027). A decrease in the level of BMI (p = 0.012) and a decrease in the concentration of triglycerides in the blood (p = 0.00000004) were detected in carriers of the CC genotype of the LRP5 rs3736228 locus. |
Databáze: | OpenAIRE |
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