USING PREPARATIVE CHROMATOGRAPHY AND NMR/LCMS/FT-IR, ISOLATION, IDENTIFICATION, AND CHARACTERIZATION OF POSACONAZOLE OXIDATIVE DEGRADATION IMPURITIES

Autor:	Naga Venkata Durga Prasad Ketha, Deepti Kolli
Rok vydání:	2022
Předmět:	General Energy General Chemical Engineering General Chemistry General Pharmacology Toxicology and Pharmaceutics Biochemistry
Zdroj:	Rasayan Journal of Chemistry. 15:619-627
ISSN:	0976-0083 0974-1496
DOI:	10.31788/rjc.2022.1516707
Popis:	Posaconazole is a pharmacological ingredient that is used to treat fungal infections. It comes in the form of delayedrelease tablets. During the forced degradation studies of Tablets, two unknown oxidative degradation impurities were discovered. The impurities were made from Posaconazole using meta-Chloroperoxybenzoic acid as an oxidant in the degradation process. Preparative chromatography was used to separate impurities, and spectroscopic techniques such as IR, NMR, and MS were used to deduce the structures. For the measurement of the total of six associated impurities of Posaconazole in Delayed-Release Tablets, a reverse phase HPLC technique was developed and validated according to ICH Q2 criteria
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c0ce78f06884fcd4a9cf4bcab73f9b56 https://doi.org/10.31788/rjc.2022.1516707 Zobrazit plný text záznamu Plný text ve formátu PDF