A diagnostically‐challenging case of melanoma ex blue nevus with comprehensive molecular analysis, including the 23‐gene expression signature (myPath melanoma)
Autor: | Joel A. Lefferts, Shaofeng Yan, Dorothea T. Barton, Anh Khoa Pham, Konstantinos Linos, Stephanie A. Castillo, Julia A. Bridge |
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Rok vydání: | 2018 |
Předmět: |
Pathology
medicine.medical_specialty Histology medicine.diagnostic_test business.industry Melanoma Cellular Blue Nevus Dermatology medicine.disease Pathology and Forensic Medicine Molecular analysis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Gene expression medicine medicine.symptom business Lymph node Blue nevus Fluorescence in situ hybridization SNP array |
Zdroj: | Journal of Cutaneous Pathology. 46:226-230 |
ISSN: | 1600-0560 0303-6987 |
DOI: | 10.1111/cup.13400 |
Popis: | Melanoma ex blue nevus (MEBN) is a rare, aggressive, and potentially lethal neoplasm. Distinguishing MEBN from an atypical cellular blue nevus can be very challenging. We report a diagnostically difficult case of MEBN with lymph node metastases, in which single nucleotide polymorphism array and fluorescence in situ hybridization were used to arrive at the correct diagnosis. It was also analyzed by the recently-introduced proprietary 23-gene expression signature test. To the best of our knowledge, this is the second reported case of MEBN analyzed by the 23-gene expression signature, which provided a false-negative result. More studies are needed to assess the sensitivity and specificity of this test in various melanocytic proliferations. |
Databáze: | OpenAIRE |
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