Synthesis and biological evaluation of indole-3-carboxamide derivatives as antioxidant agents
| Autor: | Qing-Guo Meng, David Chi Cheong Wan, Huang Erfang, Bing-Qi Zhang, Chun Hu, Jianshu Hu, Lan Zhang, Guang-Peng Meng, Chu-Ying Xiao, Jin Zhe |
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| Rok vydání: | 2019 |
| Předmět: |
Indole test
Antioxidant medicine.drug_class Chemistry medicine.medical_treatment Carboxamide 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Ascorbic acid medicine.disease_cause 01 natural sciences In vitro 0104 chemical sciences Melatonin Biochemistry Cell culture medicine 0210 nano-technology Oxidative stress medicine.drug |
| Zdroj: | Chinese Chemical Letters. 30:2157-2159 |
| ISSN: | 1001-8417 |
| Popis: | Oxidative stress results in various pathologies and as consequence antioxidant agents have attracted uninterrupted attention. In this paper, a novel series of indole-3-carboxamide derivatives (6a–6l) were designed and synthesized based on the melatonin structure as novel antioxidants. All of them were evaluated for the antioxidant activities in vitro against human neuroblastoma SH-SY5Y cell line using H2O2 radical scavenging assay. The target compounds 6a, 6f and 6i indicated better activities than the positive control, ascorbic acid, and 6a exhibited the best antioxidant activity. In addition, the structure-activity relationships of the target compounds were also preliminarily summarized based on the obtained experimental data. |
| Databáze: | OpenAIRE |
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