Design and structural investigations of Yb3+ substituted β-Ca3(PO4)2 contrast agents for bimodal NIR luminescence and X-ray CT imaging
| Autor: | Sanjeevi Kannan, Rugmani Meenambal |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Ytterbium
Materials science Aqueous solution Photoluminescence Near-infrared spectroscopy X-ray chemistry.chemical_element Bioengineering 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Biomaterials Crystallography chemistry Mechanics of Materials Attenuation coefficient 0210 nano-technology Luminescence Absorption (electromagnetic radiation) |
| Zdroj: | Materials Science and Engineering: C. 91:817-823 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2018.06.032 |
| Popis: | The quest for the development of bone substitutes with contrast agents for diagnostic imaging subsists to distinguish synthetic bone from native human tissue. To this aim, ytterbium (Yb3+) substitutions in β-tricalcium phosphate (β-Ca3(PO4)2, β-TCP) as contrast agents has been developed to differentiate implant materials thereby, facilitating as host for bimodal imaging application by means of NIR luminescence and X-ray computed tomography techniques. A facile aqueous chemical precipitation route with the aid of surfactant is used for the synthesis of Yb3+ substitutions in β-Ca3(PO4)2. The characterization results affirms the ability of β-Ca3(PO4)2 to host 4.36 mol% of Yb3+ while the excess Yb3+ crystallizes as YbPO4. The structure refinement results favour the occupancy of Yb3+ at the Ca2+(5) site of β-Ca3(PO4)2. The absorption and photoluminescence spectra in the near infrared region with emission intensity ~1024 nm in the second biological window correspond to 2F5/2 → 2F7/2 transitions of Yb3+. The designed Yb3+ substituted β-Ca3(PO4)2 does not exhibit any toxicity in human osteosarcoma cell lines and delivers an excellent in vitro CT contrast ability allied by the enhanced signal intensity and high X-ray absorption coefficient. |
| Databáze: | OpenAIRE |
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