1H HR-MAS NMR-Based Metabolomic Fingerprinting to Distinguish Morphological Similarities and Metabolic Profiles of Maytenus ilicifolia, a Brazilian Medicinal Plant
| Autor: | Frederico L.F. Soares, Katlin Suellen Rech, Sher Ali, Andersson Barison, Gul Badshah |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
010405 organic chemistry Organic Chemistry Pharmaceutical Science Plant specimen Biology 01 natural sciences 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Metabolomics Complementary and alternative medicine Drug Discovery Botany medicine Molecular Medicine Maytenus ilicifolia Classification methods Stomach ulcers medicine.symptom Nmr based metabolomics Confusion |
| Zdroj: | Journal of Natural Products. 84:1707-1714 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.0c01094 |
| Popis: | Maytenus ilicifolia or "Espinheira-Santa" is a renowned Brazilian medicinal plant usually used against intestinal and stomach ulcers. Other species with similar thorny leaves have raised great confusion in order to discern the authentic M. ilicifolia. Misidentifications can lead to product adulteration of authentic M. ilicifolia with other species, which can be found on the Brazilian market. The intake of misclassified herbal products potentially could be fatal, demanding faster reliable fingerprinting-based classification methods. In this study, the use of 1H HR-MAS NMR metabolomics fingerprinting and principal component analysis (PCA) allowed an evaluation of the authenticity for both collected and commercial M. ilicifolia samples, from the content of the flavanol, (-)-epicatechin (2), by observing variations in metabolic patterns. Plant specimen types from cultivated and natural habitats were analyzed by considering seasonal and topological differences. The interand intraplant topological metabolic profiles were found to be affected by seasonal and/or ecological trends such as sunlight, shade, rain, and the presence of pathogens. Moreover, several commercial samples, labeled as M. ilicifolia, were evaluated, but most of these products were of an inadequate quality. |
| Databáze: | OpenAIRE |
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