Increased serum uric acid levels in patients with non-valvular atrial fibrillation
| Autor: | M.S. Mourali, M. Ben Halima, B. Rekik, Sana Ouali, S. Boudiche, N. Larbi, Fathia Zghal |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Receiver operating characteristic business.industry Non valvular atrial fibrillation Increased serum uric acid Atrial fibrillation medicine.disease chemistry.chemical_compound medicine.anatomical_structure chemistry Ventricle Internal medicine Cardiology medicine Uric acid In patient Hyperuricemia Cardiology and Cardiovascular Medicine business |
| Zdroj: | Archives of Cardiovascular Diseases Supplements. 12:129-130 |
| ISSN: | 1878-6480 |
| Popis: | Background Serum uric acid (SUA) is a simple and independent marker of morbidity and mortality in a variety of cardiovascular diseases. Purpose In this study we aimed to examine the relationship between serum uric acid levels and clinical, biological and echocardiographic characterstics in patients with non-valvular atrial fibrillation (AF). Methods One hundred and seventy patients with non-valvular atrial fibrillation were included (mean age: 66.3 ± 8.5 years; 37% male patients). Hyperuricemia was defined as SUA ≥ 360 μmol/L in women and ≥ 446 μmol/L in men determined determined according to receiver operating characteristic curve. Clinical, biological and echocardiographic characterestics were compared in patients with (n = 51) and without hyperuricemia (n = 119). Results In AF patients, those with hyperuricemia had the most adverse biological risk profile including the highest rates of renal dysfunction (P Conclusion High serum uric acid levels were associated with a low left ventricle contractile function, enlargement of left atrium, inflammatory biological profile and could provide additional prognostic information on future thromboembolic events in patients with AF. |
| Databáze: | OpenAIRE |
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