Direct oxidative conversion of alkyl halides into nitriles with molecular iodine and 1,3-diiodo-5,5-dimethylhydantoin in aq ammonia

Autor:	Shinpei Iida, Ryosuke Ohmura, Hideo Togo
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Nitrile Organic Chemistry chemistry.chemical_element Halide Iodine Biochemistry Medicinal chemistry Chemical synthesis Ammonia chemistry.chemical_compound chemistry Drug Discovery Aliphatic compound Carbon Alkyl
Zdroj:	Tetrahedron. 65:6257-6262
ISSN:	0040-4020
DOI:	10.1016/j.tet.2009.05.001
Popis:	Various benzylic halides were smoothly and directly converted into the corresponding aromatic nitriles in high yields using molecular iodine and 1,3-diiodo-5,5-dimethylhydantoin, respectively, in aq ammonia. Similarly, primary alkyl halides were also converted into corresponding nitriles in moderate to good yields using molecular iodine and 1,3-diiodo-5,5-dimethylhydantoin in aq ammonia, although a long reaction time was required. The present reaction is a new method for the preparation of aromatic nitriles from benzylic halides and a new method for the conversion of alkyl halides into corresponding nitriles with retention of the number of carbon atoms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c08eb5d07609a6584f705344f26fa8b6 https://doi.org/10.1016/j.tet.2009.05.001 Zobrazit plný text záznamu Full Text from ScienceDirect